Global stability for a delayed HIV-1 infection model with nonlinear incidence of infection

Keywords: Time delay Global stability Lyapunov functional Nonlinear incidence a b s t r a c t In this paper, a delayed HIV-1 infection model with nonlinear incidence of infection is reinvestigated. It is shown that if the reproduction number R > 1, then the system is permanent , and the infective equilibrium of the system is globally asymptotically stable. Thus, the global dynamics of the system is completely determined by the reproduction number R. The results obtained enrich and improve the corresponding results given by Wang et al. A delayed HIV-1 infection model with Beddington–DeAngelis functional response, Nonlinear Dynamics 62 (2010) 67–72]. The conclusions we established also verify the numerical simulation results on the global asymptotic stability of the infective equilibrium in the paper [D. Li, W. Ma, Asymptotic properties of an HIV-1 infection model with time delay, J. Math.